The outbreak that has infected over 20,000 people and killed more than 425 in China has forced many stores and factories to close and airlines to cancel flights.
The sports apparel and footwear giant said it is "prioritizing the health and safety of our teammates and partners, in cooperation with local authorities."
"Similar to others in the marketplace, approximately half of Nike-owned stores have been temporarily closed," while it is "experiencing lower than planned retail traffic in stores that do remain open."
"In the short term, we expect the situation to have a material impact on our operations in Greater China," the company said in a statement.
Nike CEO John Donahoe, said, "Despite this difficult situation, Nike's long-term opportunity to continue to serve consumers in Greater China with inspiration and innovation remains exceedingly strong."
The company will provide an update on the financial impact when it reports quarterly results, which are due in March.
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