The ESA said it would "discontinue cooperative activities" on Luna-25, 26 and 27, a series of Russian lunar missions on which the European agency had aimed to test new equipment and technology.
In late March, collaboration on ExoMars, a plan to land a rover on Mars to drill into the soil and search for signs of life, was suspended as well.
"As with ExoMars, the Russian aggression against Ukraine and the resulting sanctions put in place represent a fundamental change of circumstances and make it impossible for ESA to implement the planned lunar cooperation," the ESA said in a statement.
The ESA had planned to have a navigation camera called Pilot-D on the Luna-25 probe, whose launch is scheduled for this summer.
ESA Director-General Josef Aschbacher told a press briefing the camera was going to be dismantled and taken off the launch, and that Russia's space agency, Roscosmos, had already been informed.
The ESA is looking for other options and partners to test the technology that would have formed part of the Russian missions, it said, adding some had already been found.
An alternative mission for Pilot-D "is already being procured from a commercial service provider", the agency said.
Equipment including a lunar drill originally planned for Luna-27 will now be launched on a NASA-led mission instead.
A study on new options for the ExoMars components was being fast-tracked as well, the ESA said.
That mission had been supposed to launch in September.
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